中期発がん性試験開発ラボ・安全性試験受託施設｜株式会社DIMS医科学研究所

２０２２年投稿

1. 土井悠子, 杉山大揮, 玉野静光, 大野晶子, 稲益悟志. レンギョウ葉エキス（RLE）のラットを用いた単回および91日反復経口投与毒性試験．薬理と治療, 50: 31-40 (2022)
 

2. Matsumoto, H., Ando, S., Yoshimoto, E., Numano, T., Sultana, N., Fukamachi, K., Iinuma, M., Okuda, K., Kimura, K., Suzui, M. Extracts of Musa basjoo induce growth inhibition and changes in the protein expression of cell cycle control molecules in human colorectal cancer cell lines. Oncology Letters, 23: 99, 2022.

２０２１年投稿

1. Numano, T., Sugiyama, T., Kawabe, M., Mera, Y., Ogawa, R., Nishioka, A., Fukui, H., Sato, K., Hagiwara, Y. Lung toxicity of a vapor-grown carbon fiber in comparison with a multi-walled carbon nanotube on F344 rats. J Toxicol Pathol, 34: 57-71, 2021.

2. Takeuchi, K., Kuroda, Y., Numano, T., Kimura, M., Hayashi, S., Furukawa, S.
Comparison of acute inhalation toxicity of sulfuric acid by the inhalation and intratracheal instillation methods. J Toxicol Pathol 2021; 34: 269-273
 

3. Sato, R., Takabe, M., Ishii, T., Imai, N., Doi, Y., Aoki, T. Genotoxicity of Monascus Color Y-001. Fundamental Toxicological Sciences, 8: 7-16, 2021.
 

4. Doi, Y., Sugiyama, T., Hagiwara, A., Imai, N., Mera, Y., Aoki, T. A 90-day oral repeated-dose toxicity study of Monascus Color Y-001 in rats. Fundamental Toxicological Sciences, 8: 37-47, 2021.
 

5. Kodama, T., Togashi, Y., Matsutani, N., Kurashige, S., Aoki, T., Otagiri, Y. Expression of miRNAs in the colon, rectum, plasma, and feces in rats with dextran sulfate sodium. Fundamental Toxicological Sciences, 8: 177-182, 2021.
 

6. 土井悠子, 原智美, 玉野静光, 大野晶子, 稲益悟志. ゴボウスプラウトエキス（GSE）のラットを用いた単回および91日反復経口投与毒性試験．薬理と治療, 49: 1095-1105 (2021)

7. 橋本宏美, 廣川真里, 岩越令恭, 住田由美, 木村正美.  EDTA脱灰組織による特殊染色に与える影響について. 実験病理組織技術研究会誌, 29: 49-54 (2021)

２０２０年投稿

1.Numano, T., Morioka, M., Higuchi, H., Uda, K., Sugiyama, T., Hagiwara, T., Doi, Y., Imai, N., Kawabe, M., Mera, Y., Tamano, S. Effects of administering different vehicles via single intratracheal instillation on responses in the lung and pleural cavity of Crl:CD(SD) rats. J Toxicol Pathol, 33: 11-19, 2020.
※日本毒性病理学会 JTP奨励賞受賞

2.Kawabe, M., Urano, K., Suguro, M., Hara, T., Kageyama, Y., Mera, Y., Tsutsumi, H. Establishment and validation of an ultra-short-term skin Carcinogenicity bioassay using Tg-rasH2 mice. Veterinary Pathology 57:192-199, 2020. 

3.Senoh,H., Kano,H., Suzuki,M., Fukushima,S., Oshima,Y., Kobayashi,T., Morimoto,Y., Izumi,H., Ota,Y., Takehara,H., Numano,T., Kawabe, M., Gamo,M., Takeshita,J., Inter-laboratory comparison of pulmonary lesions induced by intratracheal instillation of NiO nanoparticle in rats: Histopathological examination results.  Journal of Occupational Health 62:e12117, 2020.

4.Saleh, D.M., Alexander, W.T., Numano,T., Ahmed, O.H.M., Gunasekaran, S., Alexander, D.B., Abdelgied, M., El-Gazzar, A.M., Takase, H., Xu, J., Naiki-Ito, A., Takahashi, S., Hirose, A., Ohnishi, M., Kanno, J., Tsuda, H. Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat.  Particle and Fibre Toxicology 17:48, 2020.

２０１９年投稿

1.Nishimura, I., Doi, Y., Imai, N., Kawabe, M., Mera, Y., Shiina, T.　Carcinogenicity of intermediate frequency magnetic field in Tg.rasH2 mice. Bioelectromagnetics, 40:160-169, 2019.
 

2.Anzai, T., Matsuyama, T., Wasko, M., Hatakeyama, H., Horikawa, S.-I., Anzai, R., Iwata, H., Imai, N., Mizuhashi, F., Tsuboi, M., Okuzono, T., Takagi, H., Cho, H., Rong, B.T.S., Masaki, F., Nakae, D. Establishment of the global SEND alliance (G-SEND) in japan and efficient creation of electronic SEND datasets between CROs. J Toxicol. Pathol., 32:119-126, 2019.
 

3.Numano, T., Higuchi, H., Alexander, D.B., Alexander, W.T., Abdelgied, M., El-Gazzar, A.M., Saleh, D., Takase, H., Hirose, A., Naiki-Ito, A., Suzuki, S., Takahashi, S., Tsuda, H. MWCNT-7 administered to the lung by intratracheal instillation induces development of pleural mesothelioma in F344 rats. Cancer Science, 110:2485-2492, 2019.
 

4.Abdelgied, M., El-Gazzar, A.M., Alexander, W.T., Numano, T., Iigou, M., Naiki-Ito, A., Takase, H., Hirose, A., Taquahashi, Y., Kanno, J., Abdelhamid, M., Abdou, K.A., Takahashi, S., Alexander, D.B., Tsuda, H. Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration. Particle and Fibre Toxicology, 16:34, 2019.

２０１８年投稿

1.Kuroda, H., Kinomoto, T., Ogawa, S., Kawabe, M., Suguro, M., Naraoka, H., Takamatsu, K., Oishi, Y. Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model.
J Toxicol Pathol, 31: 35-41, 2018.
 

2.Ogawa, S., Kuroda, H., Kinomoto, T., Kawabata, Y., Kawabe, M., Suguro, M., Oishi, Y. Verification of a false positive in a two-year rat carcinogenicity study using dual control groups.
J Toxicol. Sci., 43: 557-563, 2018.
 

3.Iwadate, K., Yamaguchi, Y., Sasaki, M., Nakatani, M., Doi, Y., Imai, N., Tamano, S., Nishihori, Y.  Carcinogenicity study of poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132) in F344 rats. Fundamental Toxicological Sciences, 5: 127-140, 2018.

4.Abdelgied, M., El-Gazzar, A.M., Alexander,D.B., Alexander, W.T., Numano, T., ligou, M.,  Naiki-lto, A., Takase, H., Abdou,K.A., Hirose, A., Taquahashi, Y., Kanno, J., Tsuda, H., Takahashi, S.,　Potassium octatitanate fibers induce persistent lung and pleural injury and are possibly carcinogenic in male Fischer 344 rats

Cancer Science, 109:2164-2177, 2018.
 

5.Takeshita, J., Ono, J., Suzuki, T., Kano, H., Oshima, Y., Morimoto, Y., Takehara, H., Numano, T., Fujita, K., Shinohara, N., Yamamoto, K., Honda, K., Fukushima, S., Gamo, M.,　Application of ISO 5725 to evaluate measurement precision of distribution within the lung after intratracheal administration, Series on Advances in Mathematics for Applied Sciences

Advanced Mathematical and Computational Tools in Metrology and Testing XI :357-364,2018