中期発がん性試験開発ラボ 株式会社DIMS医科学研究所
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1. Numano, T., Sugiyama, T., Kawabe, M., Mera, Y., Ogawa, R., Nishioka, A., Fukui, H., Sato, K., Hagiwara, Y. Lung toxicity of a vapor-grown carbon fiber in comparison with a multi-walled carbon nanotube on F344 rats. J Toxicol Pathol, 34: 57-71, 2021.
2. Takeuchi, K., Kuroda, Y., Numano, T., Kimura, M., Hayashi, S., Furukawa, S.
Comparison of acute inhalation toxicity of sulfuric acid by the inhalation and intratracheal instillation methods. J Toxicol Pathol 2021; 34: 269-273
1.Numano, T., Morioka, M., Higuchi, H., Uda, K., Sugiyama, T., Hagiwara, T., Doi, Y., Imai, N., Kawabe, M., Mera, Y., Tamano, S. Effects of administering different vehicles via single intratracheal instillation on responses in the lung and pleural cavity of Crl:CD(SD) rats. J Toxicol Pathol, 33: 11-19, 2020.
※日本毒性病理学会 JTP奨励賞受賞
2.Kawabe, M., Urano, K., Suguro, M., Hara, T., Kageyama, Y., Mera, Y., Tsutsumi, H. Establishment and validation of an ultra-short-term skin Carcinogenicity bioassay using Tg-rasH2 mice. Veterinary Pathology 57:192-199, 2020.
3.Senoh,H., Kano,H., Suzuki,M., Fukushima,S., Oshima,Y., Kobayashi,T., Morimoto,Y., Izumi,H., Ota,Y., Takehara,H., Numano,T., Kawabe, M., Gamo,M., Takeshita,J., Inter-laboratory comparison of pulmonary lesions induced by intratracheal instillation of NiO nanoparticle in rats: Histopathological examination results. Journal of Occupational Health 62:e12117, 2020.
4.Saleh, D.M., Alexander, W.T., Numano,T., Ahmed, O.H.M., Gunasekaran, S., Alexander, D.B., Abdelgied, M., El-Gazzar, A.M., Takase, H., Xu, J., Naiki-Ito, A., Takahashi, S., Hirose, A., Ohnishi, M., Kanno, J., Tsuda, H. Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat. Particle and Fibre Toxicology 17:48, 2020.
1.Nishimura, I., Doi, Y., Imai, N., Kawabe, M., Mera, Y., Shiina, T. Carcinogenicity of intermediate frequency magnetic field in Tg.rasH2 mice. Bioelectromagnetics, 40:160-169, 2019.
2.Anzai, T., Matsuyama, T., Wasko, M., Hatakeyama, H., Horikawa, S.-I., Anzai, R., Iwata, H., Imai, N., Mizuhashi, F., Tsuboi, M., Okuzono, T., Takagi, H., Cho, H., Rong, B.T.S., Masaki, F., Nakae, D. Establishment of the global SEND alliance (G-SEND) in japan and efficient creation of electronic SEND datasets between CROs. J Toxicol. Pathol., 32:119-126, 2019.
3.Numano, T., Higuchi, H., Alexander, D.B., Alexander, W.T., Abdelgied, M., El-Gazzar, A.M., Saleh, D., Takase, H., Hirose, A., Naiki-Ito, A., Suzuki, S., Takahashi, S., Tsuda, H. MWCNT-7 administered to the lung by intratracheal instillation induces development of pleural mesothelioma in F344 rats. Cancer Science, 110:2485-2492, 2019.
4.Abdelgied, M., El-Gazzar, A.M., Alexander, W.T., Numano, T., Iigou, M., Naiki-Ito, A., Takase, H., Hirose, A., Taquahashi, Y., Kanno, J., Abdelhamid, M., Abdou, K.A., Takahashi, S., Alexander, D.B., Tsuda, H. Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration. Particle and Fibre Toxicology, 16:34, 2019.
1.Kuroda, H., Kinomoto, T., Ogawa, S., Kawabe, M., Suguro, M., Naraoka, H., Takamatsu, K., Oishi, Y. Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model.
J Toxicol Pathol, 31: 35-41, 2018.
2.Ogawa, S., Kuroda, H., Kinomoto, T., Kawabata, Y., Kawabe, M., Suguro, M., Oishi, Y. Verification of a false positive in a two-year rat carcinogenicity study using dual control groups.
J Toxicol. Sci., 43: 557-563, 2018.
Cancer Science, 109:2164-2177, 2018.
Advanced Mathematical and Computational Tools in Metrology and Testing XI :357-364,2018
1. Honda, H., Kawamoto, T., Doi, Y., Matsumura, S., Ito, Y., Imai, N., Ikeda, N., Mera, Y., Morita, O. Alpha-linolenic acid-enriched diacylglycerol oil dose not promote tumor development in tongue and gastrointestinal tract tissues in a medium-term multi-organ carcinogenesis bioassay using male F344 rat. Food Chem. Toxicol., 106: 185-192, 2017.
2. Doi, Y., Imai, N., Suguro, M., Numano, T., Furukawa, F. No carcinogenicity of poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132): 26-week feeding study using rasH2 mice. Fundamental Toxicological Sciences, 4: 137-150, 2017.
3. Shirai, T., Wang, J., Kawabe, M., Wake, K., Watanabe, S., Takahashi, S., Fujiwara, O. No adverse effects detected for simultaneous whole-body exposure to multiple-frequency radiofrequency electromagnetic fields for rats in the intrauterine and pre- and post-weaning periods. Journal of Radiation Research, 58: 48-58, 2017.
4. Suguro, M., Numano, T., Kawabe, M., Doi, Y., Imai, N., Mera, Y., and Tamano, S. Lung tumor induction by 26-week dermal application of 1,2-dichloroethane
In CB6F1-Tg rasH2 mice. Toxicologic Pathology, 45, 427-434, 2017.
１．Suzui, M., Futakuchi, M., Fukamachi, K., Numano, T., Abdelgied, M., Takahashi, S., Ohnishi, M., Omori, T., Tsuruoka, S., Hirose, A., Kanno, J., Sakamoto, Y., Alexander, D.B., Alexander, W.T., Jiegou, X., Tsuda, H. Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignamt mesothelioma and lung tumors. Cancer Sci., 107: 924-935, 2016.
２．河部真弓
発がん性評価における中期発がん性試験の位置付け. 谷本学校 毒性質問箱, 18: 71-79, 2016.
1.Kakehashi, A., Hagiwara, A., Imai, N., Wei, M., Fukushima, S., Wanibuchi, H. Induction of cell proliferation in the rat liver by the short-term administration of ethyl tertiary-butyl ether. J. Toxicol. Pathol., 28: 27-32, 2015.
2.Hagiwara,A., Doi,Y., Imai,N.,Suguro,M., Kawabe,M.,Furukawa,F., Tamano,S., Nagano,K., and Fukushima,S. Promotion of liver and kidney carcinogenesis by ethyl tertiary-butyl ether (ETBE) in male Wistar rats.J Toxicol Pathol ; 28: 189–195, 2015.
1.Xu, J., Futakuchi, M., Alexander, D. B, Fukamachi, K., Numano, T., Suzui, M., Shimizu, H., Omori, T., Kanno, J., Hirose, A., Tsuda, H. Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles. Arch. Toxicol., 88: 65-75, 2014.
2.Numano, T., Xu, J., Futakuchi, M., Fukamachi, K., Alexander, D. B, Furukawa, F., Kanno, J., Hirose, A., Tsuda, H., Suzui, M. Comparative study of toxic effects of anatase and rutile type nanosized titanium dioxide particles in vivo and in vitro. Asian Pac. J. Cancer Prev., 15: 929-935, 2014.
3.Xu, J., Alexander, D. B, Futakuchi, M., Numano, T., Fukamachi, K., Suzui, M., Omori, T., Kanno, J., Hirose, A., Tsuda, H. Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes. Cancer Sci., 105: 763-769, 2014.
4.Yokohira, M., Yamakawa, K., Nakano, Y., Numano, T., Furukawa, F., Kishi, S., Ninomiya, F., Kanie, S., Hitotsumachi, H., Saoo, K., Imaida, K. Immunohistochemical characteristics of surfactant proteins A, B, C and D in inflammatory and tumorigenic lung lesions of F344 rats. J. Toxicol. Pathol., 27: 175-182, 2014.
5.Shirai, T., Imai, N., Wang, J., Takahashi, S., Kawabe, M., Wake, K., Kawai, H., Watanabe, S., Furukawa, F., Fujiwara, O. Multigenerational effects of whole body exposure to 2.14 GHz W-CDMA cellular phone signals on brain function in rats. Bioelectromagnetics, 35: 497-511, 2014.
1.Kawabe, M., Urano, K., Suguro, M., Numano, T., Taguchi, F., Tsutsumi, H., Furukawa, F. Tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in an ultra short-term skin carcinogenesis bioassay using rasH2 mice. Veterinary Pathology 50: 903-908, 2013.
2.Hagiwara, A., Imai, N., Doi, Y., Suguro, M., Kawabe, M., Furukawa, F., Nagano, K., Fukushima, S. No promoting effect of ethyl tertiary-butyl ether (ETBE) on rat urinary bladder carcinogenesis initiated with N-Butyl- N-(4-hydroxybutyl)nitrosamine. J. Toxicol. Pathol., 26: 351-357, 2013.
3.Kakehashi, A., Hagiwara, A., Imai, N., Nagano, K., Nishimaki F., Banton, M., Wei, M., Fukushima, S., Wanibuchi, H. Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: Evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways. Toxicology and Applied Pharmacology, 273: 390-400, 2013.
4.斉藤美佐江, 勝山清加、中野健二, 位坂清嗣, 打屋尚章、阿部 寛、古川文夫. H&E染色（薄切を含む）におけるコントロールサーベイ報告. 実験病理組織技術研究会誌, 22: 7-44, 2013.
1.Imai, N., Kawabe, M., Tamano, S., Doi, Y., Nakashima, H., Suguro, M., Numano, T., Hara, T., Hagiwara, A., Furukawa, F., Kaneda, Y., Tateishi, N., Fujii, W., Kawashima, H., Shibata, H., Sakakibara, Y. Arachidonate-enriched triglyceride oil dose not promote tumor development in a rat medium-term multi-organ carcinogenesis model. Food Chem. Toxicol., 50: 2780-2791, 2012.
2.木村正美, 中野健二, 国遠かおり, 山口 肇, 今田輝義, 古川文夫, 阿部 寛, 打屋尚章. PAM染色におけるコントロールサーベイ報告. 実験病理組織技術研究会誌, 21: 1-33, 2012.
3.廣川真里, 藤原あかり, 岩越令恭, 樋口仁美, 住田由美, 古川文夫. 病理標本作製における気泡発生の要因について. 実験病理組織技術研究会誌, 21: 61-64, 2012.
4.Takahashi, M., Kato, H., Doi, Y., Hagiwara, A., Hirata-Koizumi, M., Ono, A., Kubota, R., Nishimura, T., Hirose, A. Sub-acute oral toxicity study with fullerene C60 in rats. J. Toxicol. Sci., 37: 353-361, 2012.
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