中期発がん性試験開発ラボ 株式会社DIMS医科学研究所
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1. Numano, T., Sugiyama, T., Kawabe, M., Mera, Y., Ogawa, R., Nishioka, A., Fukui, H., Sato, K., Hagiwara, Y. Lung toxicity of a vapor-grown carbon fiber in comparison with a multi-walled carbon nanotube on F344 rats. J Toxicol Pathol, 34: 57-71, 2021.
1.Numano, T., Morioka, M., Higuchi, H., Uda, K., Sugiyama, T., Hagiwara, T., Doi, Y., Imai, N., Kawabe, M., Mera, Y., Tamano, S. Effects of administering different vehicles via single intratracheal instillation on responses in the lung and pleural cavity of Crl:CD(SD) rats. J Toxicol Pathol, 33: 11-19, 2020.
2.Kawabe, M., Urano, K., Suguro, M., Hara, T., Kageyama, Y., Mera, Y., Tsutsumi, H. Establishment and validation of an ultra-short-term skin Carcinogenicity bioassay using Tg-rasH2 mice. Veterinary Pathology 57:192-199, 2020.
3.Senoh,H., Kano,H., Suzuki,M., Fukushima,S., Oshima,Y., Kobayashi,T., Morimoto,Y., Izumi,H., Ota,Y., Takehara,H., Numano,T., Kawabe, M., Gamo,M., Takeshita,J., Inter-laboratory comparison of pulmonary lesions induced by intratracheal instillation of NiO nanoparticle in rats: Histopathological examination results. Journal of Occupational Health 62:e12117, 2020.
4.Saleh, D.M., Alexander, W.T., Numano,T., Ahmed, O.H.M., Gunasekaran, S., Alexander, D.B., Abdelgied, M., El-Gazzar, A.M., Takase, H., Xu, J., Naiki-Ito, A., Takahashi, S., Hirose, A., Ohnishi, M., Kanno, J., Tsuda, H. Comparative carcinogenicity study of a thick, straight-type and a thin, tangled-type multi-walled carbon nanotube administered by intra-tracheal instillation in the rat. Particle and Fibre Toxicology 17:48, 2020.
1.Nishimura, I., Doi, Y., Imai, N., Kawabe, M., Mera, Y., Shiina, T. Carcinogenicity of intermediate frequency magnetic field in Tg.rasH2 mice. Bioelectromagnetics, 40:160-169, 2019.
2.Anzai, T., Matsuyama, T., Wasko, M., Hatakeyama, H., Horikawa, S.-I., Anzai, R., Iwata, H., Imai, N., Mizuhashi, F., Tsuboi, M., Okuzono, T., Takagi, H., Cho, H., Rong, B.T.S., Masaki, F., Nakae, D. Establishment of the global SEND alliance (G-SEND) in japan and efficient creation of electronic SEND datasets between CROs. J Toxicol. Pathol., 32:119-126, 2019.
3.Numano, T., Higuchi, H., Alexander, D.B., Alexander, W.T., Abdelgied, M., El-Gazzar, A.M., Saleh, D., Takase, H., Hirose, A., Naiki-Ito, A., Suzuki, S., Takahashi, S., Tsuda, H. MWCNT-7 administered to the lung by intratracheal instillation induces development of pleural mesothelioma in F344 rats. Cancer Science, 110:2485-2492, 2019.
4.Abdelgied, M., El-Gazzar, A.M., Alexander, W.T., Numano, T., Iigou, M., Naiki-Ito, A., Takase, H., Hirose, A., Taquahashi, Y., Kanno, J., Abdelhamid, M., Abdou, K.A., Takahashi, S., Alexander, D.B., Tsuda, H. Carcinogenic effect of potassium octatitanate (POT) fibers in the lung and pleura of male Fischer 344 rats after intrapulmonary administration. Particle and Fibre Toxicology, 16:34, 2019.
1.Kuroda, H., Kinomoto, T., Ogawa, S., Kawabe, M., Suguro, M., Naraoka, H., Takamatsu, K., Oishi, Y. Progression process and safety assessment adaptation of endometrial lesions in ENU-induced 2-stage uterine carcinogenicity in a Tg-rasH2 mouse model.
J Toxicol Pathol, 31: 35-41, 2018.
2.Ogawa, S., Kuroda, H., Kinomoto, T., Kawabata, Y., Kawabe, M., Suguro, M., Oishi, Y. Verification of a false positive in a two-year rat carcinogenicity study using dual control groups.
J Toxicol. Sci., 43: 557-563, 2018.
Cancer Science, 109:2164-2177, 2018.
Advanced Mathematical and Computational Tools in Metrology and Testing XI :357-364,2018
1. Honda, H., Kawamoto, T., Doi, Y., Matsumura, S., Ito, Y., Imai, N., Ikeda, N., Mera, Y., Morita, O. Alpha-linolenic acid-enriched diacylglycerol oil dose not promote tumor development in tongue and gastrointestinal tract tissues in a medium-term multi-organ carcinogenesis bioassay using male F344 rat. Food Chem. Toxicol., 106: 185-192, 2017.
2. Doi, Y., Imai, N., Suguro, M., Numano, T., Furukawa, F. No carcinogenicity of poly-trans-[(2-carboxyethyl) germasesquioxane] (Ge-132): 26-week feeding study using rasH2 mice. Fundamental Toxicological Sciences, 4: 137-150, 2017.
3. Shirai, T., Wang, J., Kawabe, M., Wake, K., Watanabe, S., Takahashi, S., Fujiwara, O. No adverse effects detected for simultaneous whole-body exposure to multiple-frequency radiofrequency electromagnetic fields for rats in the intrauterine and pre- and post-weaning periods. Journal of Radiation Research, 58: 48-58, 2017.
4. Suguro, M., Numano, T., Kawabe, M., Doi, Y., Imai, N., Mera, Y., and Tamano, S. Lung tumor induction by 26-week dermal application of 1,2-dichloroethane
In CB6F1-Tg rasH2 mice. Toxicologic Pathology, 45, 427-434, 2017.
１．Suzui, M., Futakuchi, M., Fukamachi, K., Numano, T., Abdelgied, M., Takahashi, S., Ohnishi, M., Omori, T., Tsuruoka, S., Hirose, A., Kanno, J., Sakamoto, Y., Alexander, D.B., Alexander, W.T., Jiegou, X., Tsuda, H. Multiwalled carbon nanotubes intratracheally instilled into the rat lung induce development of pleural malignamt mesothelioma and lung tumors. Cancer Sci., 107: 924-935, 2016.
２．河部真弓
発がん性評価における中期発がん性試験の位置付け. 谷本学校 毒性質問箱, 18: 71-79, 2016.
1.Kakehashi, A., Hagiwara, A., Imai, N., Wei, M., Fukushima, S., Wanibuchi, H. Induction of cell proliferation in the rat liver by the short-term administration of ethyl tertiary-butyl ether. J. Toxicol. Pathol., 28: 27-32, 2015.
2.Hagiwara,A., Doi,Y., Imai,N.,Suguro,M., Kawabe,M.,Furukawa,F., Tamano,S., Nagano,K., and Fukushima,S. Promotion of liver and kidney carcinogenesis by ethyl tertiary-butyl ether (ETBE) in male Wistar rats.J Toxicol Pathol ; 28: 189–195, 2015.
1.Xu, J., Futakuchi, M., Alexander, D. B, Fukamachi, K., Numano, T., Suzui, M., Shimizu, H., Omori, T., Kanno, J., Hirose, A., Tsuda, H. Nanosized zinc oxide particles do not promote DHPN-induced lung carcinogenesis but cause reversible epithelial hyperplasia of terminal bronchioles. Arch. Toxicol., 88: 65-75, 2014.
2.Numano, T., Xu, J., Futakuchi, M., Fukamachi, K., Alexander, D. B, Furukawa, F., Kanno, J., Hirose, A., Tsuda, H., Suzui, M. Comparative study of toxic effects of anatase and rutile type nanosized titanium dioxide particles in vivo and in vitro. Asian Pac. J. Cancer Prev., 15: 929-935, 2014.
3.Xu, J., Alexander, D. B, Futakuchi, M., Numano, T., Fukamachi, K., Suzui, M., Omori, T., Kanno, J., Hirose, A., Tsuda, H. Size- and shape-dependent pleural translocation, deposition, fibrogenesis, and mesothelial proliferation by multiwalled carbon nanotubes. Cancer Sci., 105: 763-769, 2014.
4.Yokohira, M., Yamakawa, K., Nakano, Y., Numano, T., Furukawa, F., Kishi, S., Ninomiya, F., Kanie, S., Hitotsumachi, H., Saoo, K., Imaida, K. Immunohistochemical characteristics of surfactant proteins A, B, C and D in inflammatory and tumorigenic lung lesions of F344 rats. J. Toxicol. Pathol., 27: 175-182, 2014.
5.Shirai, T., Imai, N., Wang, J., Takahashi, S., Kawabe, M., Wake, K., Kawai, H., Watanabe, S., Furukawa, F., Fujiwara, O. Multigenerational effects of whole body exposure to 2.14 GHz W-CDMA cellular phone signals on brain function in rats. Bioelectromagnetics, 35: 497-511, 2014.
1.Kawabe, M., Urano, K., Suguro, M., Numano, T., Taguchi, F., Tsutsumi, H., Furukawa, F. Tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in an ultra short-term skin carcinogenesis bioassay using rasH2 mice. Veterinary Pathology 50: 903-908, 2013.
2.Hagiwara, A., Imai, N., Doi, Y., Suguro, M., Kawabe, M., Furukawa, F., Nagano, K., Fukushima, S. No promoting effect of ethyl tertiary-butyl ether (ETBE) on rat urinary bladder carcinogenesis initiated with N-Butyl- N-(4-hydroxybutyl)nitrosamine. J. Toxicol. Pathol., 26: 351-357, 2013.
3.Kakehashi, A., Hagiwara, A., Imai, N., Nagano, K., Nishimaki F., Banton, M., Wei, M., Fukushima, S., Wanibuchi, H. Mode of action of ethyl tertiary-butyl ether hepatotumorigenicity in the rat: Evidence for a role of oxidative stress via activation of CAR, PXR and PPAR signaling pathways. Toxicology and Applied Pharmacology, 273: 390-400, 2013.
4.斉藤美佐江, 勝山清加、中野健二, 位坂清嗣, 打屋尚章、阿部 寛、古川文夫. H&E染色（薄切を含む）におけるコントロールサーベイ報告. 実験病理組織技術研究会誌, 22: 7-44, 2013.
1.Imai, N., Kawabe, M., Tamano, S., Doi, Y., Nakashima, H., Suguro, M., Numano, T., Hara, T., Hagiwara, A., Furukawa, F., Kaneda, Y., Tateishi, N., Fujii, W., Kawashima, H., Shibata, H., Sakakibara, Y. Arachidonate-enriched triglyceride oil dose not promote tumor development in a rat medium-term multi-organ carcinogenesis model. Food Chem. Toxicol., 50: 2780-2791, 2012.
2.木村正美, 中野健二, 国遠かおり, 山口 肇, 今田輝義, 古川文夫, 阿部 寛, 打屋尚章. PAM染色におけるコントロールサーベイ報告. 実験病理組織技術研究会誌, 21: 1-33, 2012.
3.廣川真里, 藤原あかり, 岩越令恭, 樋口仁美, 住田由美, 古川文夫. 病理標本作製における気泡発生の要因について. 実験病理組織技術研究会誌, 21: 61-64, 2012.
4.Takahashi, M., Kato, H., Doi, Y., Hagiwara, A., Hirata-Koizumi, M., Ono, A., Kubota, R., Nishimura, T., Hirose, A. Sub-acute oral toxicity study with fullerene C60 in rats. J. Toxicol. Sci., 37: 353-361, 2012.
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